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HSA/FSA Eligible
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SR01

Sertraline Support

4.8

Daily targeted nutrient support, formulated for people taking sertraline.

$49.99

30-day supply delivered monthly

Expected May 1, 2026

Free Shipping. Pause or cancel anytime.

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Clinicians Choice

913 clinicians share this on FrontrowMD

Medications Supported:

Sertraline
Zoloft
Paroxetine
Paxil
Citalopram
Celexa
Fluvoxamine
Venlafaxine
Pristiq
Vilazodone
Viibryd
Brisdelle
Trintellix
Supports:
+12

Clinically-Based Ingredients:

Folate
Folate
340 mcg DFE
(as Quatrefolic® 5-MTHF)

Clinical research shows folate is a critical determinant of antidepressant effectiveness, as inadequate levels can blunt treatment response. Quatrefolic® is selected for its clinically proven bioavailability.

Vitamin B12
Vitamin B12
400 mcg
(as methylcobalamin)

B12 is a cofactor for the synthesis of mood-regulating neurotransmitters, directly enhancing the treatment response of antidepressants. Methylated B12 is the most bioavailable form ensuring proper uptake.

Dual-Form Vitamin B6
Dual-Form Vitamin B6
25 mg
(pyridoxal-5′-phosphate + pyridoxine hydrochloride)

Vitamin B6 is a required coenzyme for serotonin and GABA synthesis, pathways targeted by antidepressant therapy. Combining both active (P-5-P) and reserve forms ensures maximum uptake.

Vitamin D3
Vitamin D3
50 mcg
(as cholecalciferol from lichen)

Vitamin D3 functions as a neurosteroid in serotonin regulation, with tricyclic antidepressants shown to interfere with its active form. Plant-based D3 is used for its stability and consistency.

Vitamin K2
Vitamin K2
90 mcg
(as menaquinone-7 from chickpea)

Vitamin K2 regulates calcium placement by directing calcium where it belongs when vitamin D is present. MK-7 is selected for its clinically validated superiority in this process.

Magnesium Glycinate
Magnesium Glycinate
60 mg
(as TRAACS® magnesium bisglycinate chelate)

Magnesium regulates neurotransmitter and stress response, supporting antidepressant response. TRAACS® Glycinate is selected for its clinically validated chelation and gastrointestinal tolerability.

Zinc Glycinate
Zinc Glycinate
12.5 mg
(as TRAACS® zinc bisglycinate chelate)

Zinc serves as a biological primer for antidepressant action by modulating key receptor and growth factor pathways. TRAACS® is selected for its clinically validated chelation.

Riboflavin (Vitamin B2)
Riboflavin (Vitamin B2)
10 mg
(as riboflavin-5'-phosphate)

Riboflavin activates folate and B6, and depletion by antidepressants can disrupt neurotransmitter synthesis required for efficacy. R-5-P is the most active form of B2, ensuring absorption.

Coenzyme Q10
Coenzyme Q10
50 mg
(as ubiquinone)

CoQ10 supports mitochondrial energy production, and some antidepressants may deplete its levels, contributing to fatigue and reduced treatment response.

Chromium Picolinate
Chromium Picolinate
200 mcg

Chromium enhances insulin sensitivity to facilitate tryptophan transport and serotonin synthesis, with strong evidence of benefit alongside antidepressants in atypical depression and carbohydrate cravings.

Antidote Complex

AntidoteComplex™ is our proprietary technology developed to optimize absorption & bioavailability

Pill

How to Use:

Take 1 capsule daily with food, in the AM.

Clean Formula Standards:

Gluten-FreeVeganGMO FreeClinically Tested

30-Day Guarantee

Request a refund within 30 days of your order delivery for your money back.

Free Shipping

US orders ship within 1-2 business days. Limited international shipping.

Flexible Plans

Reschedule your deliveries or cancel your subscription any time.

Commonly Taken Alongside:
Omeprazole Support
Omeprazole Support
Omeprazole Support
Once Daily Capsule
Birth Control Support
Birth Control Support
Birth Control Support
Once Daily Capsule
Statin Support
Statin Support
Statin Support
Once Daily Capsule
Ibuprofen Support
Ibuprofen Support
Ibuprofen Support
Once Daily Capsule
Metoprolol Support
Metoprolol Support
Metoprolol Support
Once Daily Capsule

Questions, answered.

Yes. Antidote formulas were developed to be used together, with ingredient selection and nutrient overlap carefully considered across all products. Most people choose to take more than one formula as part of their routine. As always, we recommend reviewing your supplement use with your healthcare provider.

Everyone’s body responds differently. Some people may notice changes within a few weeks, while others may require more consistent use over time. Because Antidote formulas support nutrient repletion rather than immediate effects, results are often gradual. We recommend consistent daily use for sustained support.

While most people notice symptoms associated with low nutrients, it can vary and isn't always intuitive. Blood testing is the most accurate way to evaluate nutrient levels. A healthcare provider can help interpret labs and determine whether supplementation makes sense.

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4.8 Stars
Start Feeling Better
on Your Medication

Exactly what I was missing!

I’ve been using Antidote for a few weeks now and already feel less fatigued and achey. I love that it’s just one pill per day!

Sarah P.Early Access

Easy addition to my routine.

Had no idea my medication was depleting so many things, but I’m excited to to have this product in my daily routine.

David M.Early Access

Thoughtfully Designed!

I was having daily cramps before I started taking these nutrients! I am excited to try a second formula too since they work well together.

Ashley S.Early Access